LONDON (IT BOLTWISE) – New research shows that psychedelics may work by strengthening specific brain connections linked to memory and cognition. These findings may explain why psychedelic experiences are often intense and long-lasting, potentially supporting therapeutic effects.
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Recent research in the field of psychopharmacology has further illuminated the potential of psychedelic substances to treat mental illness. Scientists have found that these substances can strengthen communication between certain brain regions responsible for memory and emotions. In particular, the connection between the claustrum and the anterior cingulate cortex is intensified under the influence of psychedelics, potentially helping to stabilize new, healthier neural pathways.
The claustrum, a region of the brain rich in serotonin receptors, plays a central role in this process. Under the influence of psychedelics, the claustrum increases its activity and increases neuronal communication with the anterior cingulate cortex. This increased activity could explain why psychedelic experiences are often so vivid and memorable. The substances appear to increase the brain’s ability to form strong memory traces, making emotionally charged or transformative experiences more deeply embedded.
The therapeutic mechanisms of psychedelics may also explain why they are successful in treating depression, post-traumatic stress disorder (PTSD), and anxiety disorders. By promoting synaptic plasticity in key areas of the brain, these substances could help alleviate the symptoms of these diseases. The research suggests that psychedelic experiences, often described as intense and unforgettable, could be crucial to success in psychiatric treatment.
The study, led by Pavel Ortinski at the University of Kentucky, examined the effects of psychedelics on male rats. It was found that activation of claustrum neurons projecting to the anterior cingulate cortex under the influence of psychedelic drugs strengthened the projections to these neurons. This enhancement did not occur under normal conditions, suggesting that psychedelics have a unique ability to promote synaptic plasticity in key neural circuits.
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